Chiral Synthesis via Organoboranes. 40. Selective Reductions. 55. A Simple One-Pot Synthesis of the Enantiomers of Trifluoromethyloxirane. A General Synthesis in …

PV Ramachandran, B Gong…

Index: Ramachandran, P. Veeraraghavan; Gong, Baoqing; Brown, Herbert C. Journal of Organic Chemistry, 1995 , vol. 60, # 1 p. 41 - 46

Full Text: HTML

Citation Number: 106

Abstract

The growing importance of chiral fluoroorganic molecules in modern organic chemistry3 compelled us to include them in our general program of asymmetric synthesis via chiral organoboranes. Accordingly, we studied the asymmetric reduction of fluorinated ketones with one of the successful asymmetric reducing agents introduced by us a decade ago," B- chlorodiisopinocampheylborane (DIP-Chloride, lIa5 Apart from revealing several very ...