L??Proline??Catalyzed Activation of Methyl Ketones or Active Methylene Compounds and DMF??DMA for Syntheses of (2E)??3??Dimethylamino??2??propen??1??ones

…, P Chopra, MI Ansari, AK Chakraborti

Index: Kumar, Dinesh; Kommi, Damodara N.; Chopra, Pradeep; Ansari, Md Imam; Chakraborti, Asit K. European Journal of Organic Chemistry, 2012 , # 32 p. 6407 - 6413,7

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Citation Number: 10

Abstract

Abstract A cascade organocatalysis is reported for the nucleophilic and electrophilic dual activation taking place in the reaction of methyl ketones or active methylene compounds with DMF-DMA (N, N-dimethylformamide dimethyl acetal). L-Proline serves as an efficient organocatalyst in the covalent and noncovalent synchronous mode for the ambiphilic activation of various aryl, heteroaryl, and styryl methyl ketones, cyclic ketones, and 1, 3- ...