Organic letters

Asymmetric transfer hydrogenation of 1-naphthyl ketones by an ansa-Ru (II) complex of a DPEN-SO2N (Me)-(CH2) 2 (η6-p-Tol) combined ligand

A Kisic, M Stephan, B Mohar

Index: Kisic, Andrea; Stephan, Michel; Mohar, Barbara Organic Letters, 2013 , vol. 15, # 7 p. 1614 - 1617

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Citation Number: 19

Abstract

The first second-generation designer Ru (II) catalyst 1b featuring an enantiopure N, C-(N- ethylene-N-methyl-sulfamoyl)-tethered (DPEN-κ2 N, N′)/η6-toluene hybrid ligand is introduced. Using an S/C= 1000 in HCO2H–Et3N 5: 2 transfer hydrogenation medium, secondary 1-naphthyl alcohols are obtained in up to> 99.9% ee under mild conditions. Mechanistic factors are discussed.