Comparison of flow and batch polymerization processes for production of vinyl ether terpolymers for use in the delivery of siRNA

…, BW Thuronyi, JM Williams, L DiMichele…

Index: Nyrop, Jason L.; Soheili, Arash; Xiang, Rong; Meng, Fanyu; Waldman, Jacob H.; Jia, Xiujuan; Parmar, Rubina Giarre; Thuronyi, Benjamin W.; Williams, J. Michael; Dimichele, Lisa; Journet, Michel; Howell, Bonnie J.; Mao, Bing; Davies, Ian W.; Colletti, Steven L.; Sepp-Lorenzino, Laura; Guidry, Erin N. Journal of Polymer Science, Part A: Polymer Chemistry, 2014 , vol. 52, # 8 p. 1119 - 1129

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Abstract

ABSTRACT Synthetic polymers represent a modifiable class of materials that can serve as adjuvants to address challenges in numerous biomedical and medicinal chemistry applications including the delivery of siRNA. Polymer-based therapeutics offer unique challenges in both synthesis and characterization as compared to small molecule therapeutics. The ability to control the structure of the polymer is critical in creating a ...