Adrenergic agents. 3. Synthesis and adrenergic activity of some catecholamine analogs bearing a substituted sulfonyl or sulfonylalkyl group in the meta position

…, MS Schwartz, DF Colella, JR Wardell Jr

Index: Kaiser; Schwartz; Colella; Wardell Jr. Journal of Medicinal Chemistry, 1975 , vol. 18, # 7 p. 674 - 683

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Citation Number: 26

Abstract

12 13-27 (Table V) the 4'-benzyloxy-2-bromo-3'-substituted aceto-and butyrophenones ll to the catecholamine relatives 13-27 (Table V). One of these sequences involved DMSO oxidation of 11 to a glyoxal derivative 12 which was transformed to the catecholamine analog by amination with the appropriate primary amine followed by subsequent reduction and hydrogenolysis of the resulting imino ketone. The second, more conventional ...