Abstract Direct synthesis of racemic aromatic α-hydroxyacetic acid esters via Friedel-Crafts reaction of nonactivated, simple arenes with ethyl glyoxylate promoted by SnCl 4 or AlCl 3 is described. The use of SnCl 4 opens a fast access to various alkyl-and aryl-substituted mandelic acids esters at room temperature within two hours in good yield (> 80%) and with high regioselectivity. The procedure was successfully employed also for the alkylation of ...
[Epstein, Joseph W.; Brabander, Herbert J.; Fanshawe, William J.; Hofmann, Corris M.; McKenzie, Thomas C.; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 481 - 490]
[Epstein, Joseph W.; Brabander, Herbert J.; Fanshawe, William J.; Hofmann, Corris M.; McKenzie, Thomas C.; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 481 - 490]