Abstract The synthesis and anticonvulsant properties of new N-Mannich bases of 3-phenyl- (9a–d), 3-(2-chlorophenyl)-(10a–d), 3-(3-chlorophenyl)-(11a–d) and 3-(4-chlorophenyl)- pyrrolidine-2, 5-diones (12a–d) were described. The key synthetic strategies involve the formation of 3-substituted pyrrolidine-2, 5-diones (5–8), and then aminoalkylation reaction (Mannich-type) with formaldehyde and corresponding secondary amines, which let to ...
