Journal of Fluorine Chemistry

New synthetic routes to β-fluoro β-phenyllactic acid derivatives and β-fluorocyanohydrins

AI Ayi, M Remli, R Condom, R Guedj

Index: Ayi, A. I.; Remli, M.; Condom, R.; Guedj, R. Journal of Fluorine Chemistry, 1981 , vol. 17, p. 565 - 580

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Citation Number: 34

Abstract

Abstract Alkyl phenyl 2, 3-epoxycarboxylates from the well-known Darzens glycidic esters synthesis react under very mild conditions with pyridinium-poly-hydrogen fluoride to give corresponding 3-fluoro 3-phenyllactates in almost quantitative yields with a high regio and stereoselectivity.

~68%

~86%

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