Chemical conversion of folic acid to pteroic acid

…, JD Rose, JA Montgomery

Index: Temple, Carroll; Rose, Jerry D.; Montgomery, John A. Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3666 - 3667

Full Text: HTML

Citation Number: 7

Abstract

Treatment of folic acid with acetic anhydride in acetic acid gave a mixture of acetylated azlactones, which are cleaved with mild base at room temperature to give mainly acetylated pteroic acids. Removal of the acetyl groups from the componenta of this mixture with hot base gave pteroic acid in 5540% yield contaminated with folic acid. Although treatment of folic acid with base gave about a 21% yield of pteroic acid as determined by high-prttssure ...