Abstract A new four step synthesis of prazosin, 2-[4-(2-furoyl) piperazin-l-yl]-4-amino-6, 7- dimethoxyquinazoline, has been described. The method is also adaptable for the preparation of other substituted 4-aminoquinazolines. The yields are good in every step and the reactions are performed with ease. Prazosin hydrochloride of high purity is obtained directly in the last step.
