e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily
…, O Berteau, M Hyvönen, F Hollfelder
Index: Van Loo, Bert; Jonas, Stefanie; Babtie, Ann C.; Benjdia, Alhosna; Berteau, Olivier; Hyvoenen, Marko; Hollfelder, Florian Proceedings of the National Academy of Sciences of the United States of America, 2010 , vol. 107, # 7 p. 2740 - 2745
Abstract We report a catalytically promiscuous enzyme able to efficiently promote the hydrolysis of six different substrate classes. Originally assigned as a phosphonate monoester hydrolase (PMH) this enzyme exhibits substantial second-order rate accelerations ((k cat/KM)/kw), ranging from 10 7 to as high as 10 19, for the hydrolyses of phosphate mono-, di-, and triesters, phosphonate monoesters, sulfate monoesters, and ...
