A new synthetic strategy for the synthesis of novel 6-methyl-3′-aryl spiro [isoxazolo [2, 3- b][1, 2, 4] thiadiazole-2, 2′-thiazolidin]-4′-ones (9a–9e) and 6-methyl-3′-aryl spiro [isoxazolo [2, 3-b][1, 2, 4] oxadiazole-2, 2′-thiazolidin]-4′-ones (12a–12e) analogs is described. These compounds showed significant antimicrobial activity against all the standard strains.
