Abstract-New N-derivatives of isatin were synthesized by treating ethyl chloroacetate, N-(2-chloroethyl)- morpholine, and 1,4-di(chloromethyl)benzene with isatin sodium salt. N-Derivatives of isatin and 5-bromo- isatin were also prepared by Mannich reaction. ... In extension of our studies in the field of isatin chemistry [134] we carried out syntheses of new N-substituted derivatives of isatin and 5-bromoisatin. ... We established that reaction of isatin (I) in the form of its ...