Enantioselective CÀH activation has been a longstanding challenge in catalysis and organic chemistry. The insertion of metal-bound carbenes or nitrenes into CÀH bonds has been employed to develop highly enantioselective carbon–carbon and carbon–nitrogen bond- forming reactions.[1] The enantioselective lithiation of C (sp3) ÀH bonds adjacent to the nitrogen atom in N-tert-butyloxycarbonylpyrrolidine using sec-BuLi/(À) sparteine has ...
