ZnCl 2 catalyzed efficient synthesis of 1, 3, 4-oxadiazole and 1, 3, 4-thiadiazole

…, MR Karim, M Arifuzzaman, TA Siddiquee, AH Mirza

Index: Rahman, Md.A.; Karim, Mohammad R.; Arifuzzaman, Md.; Siddiquee, Tasneem A.; Mirza, Aminul H. Tetrahedron Letters, 2014 , vol. 55, # 21 p. 3267 - 3273

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Abstract

Abstract New methods for the synthesis of 1, 3, 4-oxadiazole and 1, 3, 4-thiadiazole have been described. No cyclizations took place in the absence of ZnCl 2. 1, 3, 4-Thiadiazoles are formed in the presence of ZnCl 2 alone, whereas oxadiazoles are produced when a base such as Et 3 N or KOH was used along with ZnCl 2.% Yields are optimized.