Synthesis of. alpha.-dehydrobiotin

GF Field, WJ Zally, LH Sternbach…

Index: Field,F.G. et al. Journal of Organic Chemistry, 1976 , vol. 41, # 24 p. 3853 - 3857

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Citation Number: 14

Abstract

1 consequence of its antibiotic activity against a variety of bacteria and fungi. 2 Subsequently, it was reported that adehydrobiotin is accompanied by two other biotin antagonist~~ and that it is a product of the catabolism of bi~ tin.~ We undertook synthesis of this biologically interesting molecule since we had available experience and intermediates derivingfrom the synthesis of biotin it~ elf.~ The approach we followed was to divert the ...