e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Aroylations of N, N-dimethylglycinonitrile to form. alpha.-dimethylamino-. beta.-oxonitriles. Cyclizations with acetophenone to give 3-dimethylamino-2-pyridones
RE Smith, GF Morris, CR Hauser
Index: Smith,R.E. et al. Journal of Organic Chemistry, 1968 , vol. 33, # 6 p. 2562 - 2564
83 that about two-thirds of 2a exists in the enol form which, in spite of distortion of the normal bond angles of the ethylene system, appears to be stabilized by hydrogen bonding as indicated in 4. Such distortion may be mitigated somewhat by conjugation of the ethylniec double bond with both the phenyl and cyanide groups. Another possibility for stabilization of the enol form might arise through the enamine type of resonance. Molecular weight ...
