Rhodium??Catalyzed Oxidative C–H Activation/Cyclization for the Synthesis of Phosphaisocoumarins and Phosphorous 2??Pyrones

Y Park, J Seo, S Park, EJ Yoo…

Index: Park, Youngchul; Seo, Jungmin; Park, Sangjune; Yoo, Eun Jeong; Lee, Phil Ho Chemistry - A European Journal, 2013 , vol. 19, # 48 p. 16461 - 16468

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Citation Number: 25

Abstract

Abstract Rhodium-catalyzed cyclization of phosphinic acids and phosphonic monoesters with alkynes has been developed. The oxidative annulation proceeds with complete conversion of phosphinic acid derivatives and allowed the atom-economic preparation of useful phosphaisocoumarins with high yield and selectivity. The reaction is tolerant of extensive substitution on the phosphinic acid, phosphonic monoester and alkyne, ...