New class of potent antinociceptive and antiplatelet 10H-phenothiazine-1-acylhydrazone derivatives

GA Silva, LMM Costa, FCF Brito, ALP Miranda…

Index: Silva, Gildasio A.; Costa, Luciana M. M.; Brito, Fernanda C. F.; Miranda, Ana L. P.; Barreiro, Eliezer J.; Fraga, Carlos A. M. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 12 p. 3149 - 3158

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Citation Number: 127

Abstract

In this work, we reported the synthesis and evaluation of the analgesic, antiinflammatory, and antiplatelet properties of new phenothiazine-attached acylhydrazone derivatives (6), designed exploring the molecular hybridization approach between antipsychotic chlorpromazine (4) and other heterocyclic derivatives (3) and (5) developed at LASSBio. Target compounds were synthesized in very good yields exploiting diphenylamine (7) as ...