Engineering of indole-based tethered biheterocyclic alkaloid meridianin into β-carboline-derived tetracyclic polyheterocycles via amino functionalization/6- …

PK Agarwal, MD Dathi, M Saifuddin…

Index: Agarwal, Piyush K.; Dathi, Meena D.; Saifuddin, Mohammad; Kundu, Bijoy Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1901 - 1908

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Citation Number: 5

Abstract

Abstract A mild, efficient and versatile method has been developed for the construction of a functionalized natural product, meridianin, and its post conversion to pyrimido-β-carboline by cationic π-cyclization. The strategy involves the introduction of an amino group at the C-5 of the pyrimidine ring and utilizing the nucleophilictiy of the C-2 in the indole ring to facilitate cationic π-cyclization.