Journal of organometallic chemistry

Esters α-méthyléniques par substitution d'éthers et d'acétates dérivés de l'α-(hydroxyméthyl) acrylate d'éthyle

H Amri, M Rambaud, J Villiéras

Index: Amri, Hassen; Rambaud, Monique; Villieras, Jean Journal of Organometallic Chemistry, 1990 , vol. 384, p. 1 - 11

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Citation Number: 32

Abstract

Abstract α-(Methylene) alkanoic esters are prepared in high yields by substitution of α- (acetoxymethyl) acrylates using Grignard reagents in the presence of a catalytic amount of copper (I) salt. This reaction can be applied to lithium enolates of esters and ketones and to give functional α-(methylene) alkanoic esters, products of great interest for the synthesis of active biological compounds (sarkomycin, α-(methylene) δ-valerolactone).

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