Bulletin of the Chemical Society of Japan

Some Unexpected Reactions in the Synthesis of 1-Phenyl-2-aminopropane-1, 3-diol Starting from Phenyl β-Chlorovinyl Ketone

H Shirahama, T Matsumoto

Index: Shirahama,H.; Matsumoto,T. Bulletin of the Chemical Society of Japan, 1965 , vol. 38, p. 1293 - 1297

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Citation Number: 2

Abstract

Fig. 3 alcohol would give favorable results. However, the reaction did not proceed in benzyl alcohol, and the original material was recovered after a few days treatment. 35 The inertness of II in a benzyl alcoholic solution may be due to the steric hindrance exerted by the benzyloxy group and/or to the polarity of the solvent. Route 2.—The experiments outlined in Fig. 3 were originally attempted in order to convert VII to a-acetamido-| 8- ...