Selective reduction of 2, 4??dinitro??and 4, 5??dinitroimidazole derivatives using iron dust

…, J Żwawiak, L Zaprutko

Index: Olender, Dorota; Zwawiak, Justyna; Zaprutko, Lucjusz Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 5 p. 1049 - 1055

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Citation Number: 9

Abstract

Imidazoles and their derivatives are very important group of compounds for their pharmacological properties [1, 2]. Particularly, the nitroimidazole class of medicines mainly shows activity against bacteria [3, 4]. Also, these drugs have become the important agents for treatment of serious infections caused by protozoa. Some of them have been tested against HIV [5]. 2-Nitroimidazoles played a major role as bioreductive markers for tumour ...