Asymmetric synthesis of secondary alcohols from primary alcohols via intramolecular carbenoid C–H insertion catalyzed by rhodium (ii) 3-phenylcholestane-2- …

CH Hwang, YH Chong, SY Song, HS Kwak…

Index: Hwang, Cheol Hee; Chong, You Hoon; Song, Sue Yeon; Kwak, Hyo Shin; Lee, Eun Chemical Communications, 2004 , # 7 p. 816 - 817

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Citation Number: 5

Abstract

Chiral secondary alcohols may be prepared from primary alcohols via asymmetric C–H insertion reactions of α′-alkoxy-α-diazoketones catalyzed by rhodium(II) (2R,3R)-3-phenylcholestane -2-carboxylate. ... Scheme 1 Chiral tertiary alcohol preparation via C–H insertion reaction. ... Preparation of chiral secondary alcohols from achiral primary alcohols presents a completely different and more difficult problem. Asymmetric C–H insertion reaction of α′-alkoxy-α- ...