Type II diabetes-related enzyme inhibition and molecular modeling study of a novel series of pyrazolone derivatives

S Shetty, B Kalluraya, SK Peethambar…

Index: Shetty, Shobhitha; Kalluraya, Balakrishna; Nithinchandra; Peethambar; Telkar, Sandeep B. Medicinal Chemistry Research, 2014 , vol. 23, # 6 p. 2834 - 2846

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Abstract

Abstract Inhibitors of alpha-amylase are targets for the development of novel drugs for the treatment of diabetes and obesity. Alpha amylase is an enzyme which increases the bio availability of glucose in the blood. Hence, the inhibition effects of alpha amylase of 2-[1-(4- isobutylphenyl) ethyl]-5-methyl-4-[2-(aryl-substituted) hydrazinylidene]-2, 4-dihydro-3 H- pyrazol-3-one (4a–l) were investigated, among them compounds 4d, 4f, 4a, and 4g have ...