'Click Synthesis' of Some Novel O??Substituted Oximes Containing 1, 2, 3??Triazole??1, 4??diyl Residues as New Analogs of β??Adrenoceptor Antagonists

…, F Karimitabar, A Khalafi??Nezhad

Index: Rad, Mohammad Navid Soltani; Behrouz, Somayeh; Karimitabar, Fatemeh; Khalafi-Nezhad, Ali Helvetica Chimica Acta, 2012 , vol. 95, # 3 p. 491 - 501

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Citation Number: 7

Abstract

Abstract The 'click synthesis' of some novel O-substituted oximes, 7a–7t, which contain 1, 2, 3-triazolediyl residues, as new analogs of β-adrenoceptor antagonists is described (Schemes 1–4). The synthesis of these compounds was achieved in four to five steps. The formation of oximes of 9H-fluoren-9-one and benzophenone, ie, 9a and 9b, respectively, followed by their reaction with propargyl bromide, afforded O-propargyl oximes 10a and ...