Tetrahedron

Synthesis of 12-oxobenzo [c] phenanthridinones and 4-substituted 3-arylisoquinolones via Vilsmeier–Haack reaction

DB Khadka, SH Yang, SH Cho, C Zhao, WJ Cho

Index: Khadka, Daulat Bikram; Yang, Su Hui; Cho, Suk Hee; Zhao, Chao; Cho, Won-Jea Tetrahedron, 2012 , vol. 68, # 1 p. 250 - 261

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Citation Number: 8

Abstract

Vilsmeier–Haack reaction on 3-arylisoquinolones resulted in versatile 4-formylated 3- arylisoquinolones that were further derivatized into 12-oxobenzo [c] phenanthridinones, 4- alkoxymethyl-3-arylisoquinolones, 3-aryl-4-phenoxymethylisoquinolones, 4-aminomethyl-3- arylisquinolone, and 3-isoquinolinyl-2-phenyl-acrylonitrile by different synthetic strategies.