Generation of the neurotoxin 6-hydroxydopamine by peroxidase/H2O2 oxidation of dopamine

A Napolitano, O Crescenzi, A Pezzella…

Index: Napolitano, Alessandra; Crescenzi, Orlando; Pezzella, Alessandro; Prota, Giuseppe Journal of Medicinal Chemistry, 1995 , vol. 38, # 6 p. 917 - 922

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Citation Number: 80

Abstract

At physiological pH values, oxidation of the neurotransmitter dopamine (DA) by the peroxidase/HzOz system leads to, besides dopaminochrome and 5, 6-dihydroxyindole resulting from oxidative cyclization of dopaminequinone (DQ), significant amounts of the neurotoxin 6-hydroxydopamine (6-OHDA) in the oxidized quinonoid form (topaminequinone, TQ). Formation of TQ was shown to depend critically on the presence of hydrogen ...