Asymmetric reductions of ethyl 2-(benzamidomethyl)-3-oxobutanoate by yeasts

R Gandolfi, E Cesarotti, F Molinari, D Romano…

Index: Gandolfi, Raffaella; Cesarotti, Edoardo; Molinari, Francesco; Romano, Diego; Rimoldi, Isabella Tetrahedron Asymmetry, 2009 , vol. 20, # 4 p. 411 - 414

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Citation Number: 13

Abstract

The stereoselective reduction of ethyl 2-(benzamidomethyl)-3-oxobutanoate 1 using yeasts was investigated among a restricted number (12) of yeasts. Kluyveromyces marxianusvar. lactis CL69 diastereoselectively produced (2R, 3S)-ethyl 2-(benzamidomethyl)-3- hydroxybutanoate 2, whereas Pichia glucozyma CBS 5766 gave (2S, 3S)-2 as the major stereoisomer. The biotransformations were independently optimized for minimizing by- ...