A Convenient Synthesis Method for Methylenomycin B and Its Application to Methylenomycin A

K Tonari, K Machiya, I Ichimoto…

Index: Tonari Machiya Ichimoto; Ueda Agricultural and Biological Chemistry, 1981 , vol. 45, # 1 p. 295 - 300

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Citation Number: 11

Abstract

A convenient synthesis method for methylenomycin B and its homolog, methylenomycin A, has been developed. Methylenomycin B, 2, 3-dimethyl-5-methylene-2-cyclopentenone (3) was synthesized: i) by methylation of Mannich derivative prepared from morpholine and 2, 3- dimethyl-2-cyclopentenone (5) or ii) by treatment of formalin with sodio derivatives of 2, 3- dimethyl-5-formyl-2-cyclopentenone (7a) and 2, 3-dimethyl-5-ethoxalyl-2-cyclopentenone ...