Discovery of potent and selective inhibitors of 11β-HSD1 for the treatment of metabolic syndrome

S Richards, B Sorensen, H Jae, M Winn, Y Chen…

Index: Richards, Steven; Sorensen, Bryan; Jae, Hwan-soo; Winn, Marty; Chen, Yixian; Wang, Jiahong; Fung, Steven; Monzon, Katina; Frevert, Ernst U.; Jacobson, Peer; Sham, Hing; Link Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 24 p. 6241 - 6245

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Citation Number: 29

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... High throughput screening efforts have identified a novel class of dichloroaniline amide 11β-HSD1 inhibitors. SAR studies initiated from dichloroaniline 4 focused on retaining the potency and selectivity profile of the lead. ... High throughput screening efforts have identified a novel class of ...