Synthesis of some new biologically active 1, 3, 4-oxadiazolyl nitroindoles and a modified Fischer indole synthesis of ethyl nitro indole-2-carboxylates

…, BV Ashalatha, KKV Raj, J Fernandes…

Index: Narayana; Ashalatha; Vijaya Raj; Fernandes; Sarojini Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 15 p. 4638 - 4644

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Citation Number: 53

Abstract

An efficient and modified synthesis of ethyl-4-nitro/5-nitro/6-nitro and 7-nitroindole-2- carboxylates is described. Carbohydrazides of corresponding ethyl nitroindole-2- carboxylates underwent smooth one-step transformation to 1, 3, 4-oxadiazolyl nitroindoles (4a–l) on reaction with aromatic carboxylic acids in the presence of phosphorus oxychloride. An alternate method to synthesize 1, 3, 4-oxadiazolyl nitroindoles is also described. ...