e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron
Reaction of Arylpropargyl Aldehydes with 2, 3-Bis-hydroxylamino-2, 3-dimethylbutane: Synthesis of 2-(1-Hydroxy-4, 4, 5, 5-tetramethylimidazolidin-2-ylidene)-1- …
EV Tretyakov, AV Tkachev, TV Rybalova, YV Gatilov…
Index: Tretyakov, Eugene V; Tkachev, Alexey V; Rybalova, Tatyana V; Gatilov, Yurii V; Knight, David W; Vasilevsky, Sergey F Tetrahedron, 2000 , vol. 56, # 51 p. 10075 - 10080
Reaction of arylpropargyl aldehydes with 2, 3-dihydroxylamino-2, 3-dimethylbutane results in the formation of 2-(1-hydroxy-4, 4, 5, 5-tetramethylimidazolidin-2-ylidene)-1- arylethanones in high yields (70–80%). Allowing availability of propargyl aldehydes, this method gives new possibilities for the preparation of 2-(1-hydroxy-4, 4, 5, 5- tetramethylimidazolidin-2-ylidene)-1-arylethanones.