Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities

KS Kim, SD Kimball, RN Misra…

Index: Journal of Medicinal Chemistry, , vol. 45, # 18 p. 3905 - 3927

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Citation Number: 153

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. 2-Amino-5-thiocyanatothiazole 2 was prepared by reacting 2-aminothiazole with sodium thiocyanate and bromine (Scheme 1). 12 Acylation of the 2-amino-5-thiocyanatothiazole ...

N-(cycloalkylamino) acyl-2-aminothiazole inhibitors of cycli...

[Misra, Raj N.; Xiao, Hai-Yun; Kim, Kyoung S.; Lu, Songfeng; Han, Wen-Ching; Barbosa, Stephanie A.; Hunt, John T.; Rawlins, David B.; Shan, Weifang; Ahmed, Syed Z.; Qian, Ligang; Chen, Bang-Chi; Zhao, Rulin; Bednarz, Mark S.; Kellar, Kristen A.; Mulheron, Janet G.; Batorsky, Roberta; Roongta, Urvashi; Kamath, Amrita; Marathe, Punit; Ranadive, Sunanda A.; Sack, John S.; Tokarski, John S.; Pavletich, Nikola P.; Lee, Francis Y. F.; Webster, Kevin R.; Kimball, S. David Journal of Medicinal Chemistry, 2004 , vol. 47, # 7 p. 1719 - 1728]

N-(cycloalkylamino) acyl-2-aminothiazole inhibitors of cycli...

[Journal of Medicinal Chemistry, , vol. 47, # 7 p. 1719 - 1728]