Design, synthesis and pharmacological profile of novel dopamine D2 receptor ligands

…, A El-Nabawi, AT Eldefrawi, EX Albuquerque…

Index: Menegatti, Ricardo; Cunha, Anna C.; Ferreira, Vitor F.; Perreira, Edna F. R.; El-Nabawi, Ahmed; Eldefrawi, Amira T.; Albuquerque, Edson X.; Neves, Gilda; Rates, Stela M. K.; Fraga, Carlos A. M.; Barreiro, Eliezer J. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4807 - 4813

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Citation Number: 70

Abstract

The present study describes the synthesis and pharmacological profile of three novel heterocyclic compounds originally designed, on the basis of bioisosterism, as dopamine D2 receptor ligands: 1-[1-(4-chlorophenyl)-1H-pyrazol-4-ylmethyl]-4-phenyl-piperazine (LASSBio-579), 1-phenyl-4-(1-phenyl-1H-[1, 2, 3] triazol-4-ylmethyl)-piperazine (LASSBio- 580) and 1-[1-(4-chlorophenyl)-1H-[1, 2, 3] triazol-4-ylmethyl]-4-phenyl-piperazine ( ...