A Rhodium??Catalyzed Tandem Alkyne Dimerization/1, 4??Addition Reaction

…, CM Russo, JE Marquez, JD Chisholm

Index: Lerum, Ronald V.; Russo, Christopher M.; Marquez, Jocellie E.; Chisholm, John D. Advanced Synthesis and Catalysis, 2013 , vol. 355, # 17 p. 3485 - 3491

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Citation Number: 2

Abstract

Abstract: A convenient three-component coupling reaction for the construction of conjugated enynes using rhodium catalysis is reported. Dimerization of a monosubstituted alkyne followed by trapping of the vinyl metal intermediate with an electron-deficient alkene, such as methyl vinyl ketone, provided moderate to good yields of these enynes. The use of the hindered electron-rich tris (ortho-tolyl) phosphine as a ligand for the rhodium catalyst ...