2, 3-Dihydro-6, 7-dichloro-pyrido [2, 3-b] pyrazine-8-oxide as selective glycine antagonist with in vivo activity

…, D Donati, A Missio, A Pecunioso, A Reggiani…

Index: Micheli, Fabrizio; Cugola, Alfredo; Donati, Daniele; Missio, Andrea; Pecunioso, Angelo; Reggiani, Angelo; Tarzia, Giorgio Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 12 p. 2129 - 2132

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Citation Number: 8

Abstract

2, 3-Dihydro-6, 7-dichloro-pyrido [2, 3-b] pyrazine-8-oxide was synthesized and evaluated for in vitro/in vivo antagonistic activity at the strychnine insensitive glycine binding site on the NMDA receptor revealing it to be a useful tool to evaluate the effectiveness of glycine antagonists in vivo.