The use of small molecule probes to study spatially separated stimulus-induced signaling pathways

…, C Gloeckner, GN Stowe, YJ Kang, PS Tobias…

Index: Kravchenko, Vladimir V.; Gloeckner, Christian; Stowe, G. Neil; Kang, Young J.; Tobias, Peter S.; Mathison, John C.; Ulevitch, Richard J.; Kaufmann, Gunnar F.; Janda, Kim D. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 2043 - 2045

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Citation Number: 2

Abstract

Simultaneous activation of signaling pathways requires dynamic assembly of higher-order protein complexes at the cytoplasmic domains of membrane-associated receptors in a stimulus-specific manner. Here, using the paradigm of cellular activation through cytokine and innate immune receptors, we demonstrate the proof-of-principle application of small molecule probes for the dissection of receptor-proximal signaling processes, such as ...