The syntheses of eight 2-alkylamino-4-aminobutyric acids are described. The starting material is 4-butyrolactone, which is opened with potassium phthalimide to give 4- phthalimidobutyric acid. After bromination the 2-bromo-4-phthalimidobutyric acid, obtained in excellent yield, is treated with aliphatic amines in alcoholic medium to give the desired substituted 2, 4-diaminobutyric acids, which were characterized as the ...
