Journal of medicinal chemistry

N-[[(Mercaptoacetyl) amino] benzoyl] glycines mucolytic agents

TA Martin, WT Comer

Index: Martin, Tellis A.; Comer, William T. Journal of Medicinal Chemistry, 1985 , vol. 28, # 7 p. 910 - 914

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Citation Number: 4

Abstract

Indiana 47721. Received August 3, 1984 m-and p-aminobenzoic acids were converted to the title compounds by sequential use of ClCH, COCl, SOCl,, glycine methyl or ethyl ester, AcSK, and hydrolysis. The title compounds and a number of salts were compared for mucolytic activity, toxicity, stability, and hygroscopicity. When compared to N-acetyl-L- cysteine (NAC), the compounds exhibit several times the in vitro mycolytic activity of NAC ...