e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Haloacetylated enol ethers 10. Condensation of β-alkoxyvinyl trifluoromethyl ketones with thiosemicarbazide. Synthesis of new trifluoromethyl 4, 5-dihydro-1H-1- …
HG Bonacorso, AD Wastowski, N Zanatta…
Index: Bonacorso; Wastowski; Zanatta; Martins; Naue Journal of Fluorine Chemistry, 1998 , vol. 92, # 1 p. 23 - 26
The synthesis of 3-aryl [alkyl]-5-hydroxy-5-trifluoromethyl-4, 5-dihydro-1H-1- pyrazolethiocarboxyamides (2a–g) from the direct cyclo-condensation reaction of β- alkoxyvinyl trifluoromethyl ketones (1a–g) with thiosemicarbazide in methanol, under mild conditions, is reported. Similarly, the 1H-1-pyrazolethiocarboxyamide derivatives (2a–g) were easily dehydrated and the thiocarboxyamide group hydrolyzed in a one-step ...
