Synthesis and Antimicrobial Activities of Oximes Derived from O??Benzylhydroxylamine as FabH Inhibitors

…, LR Zhang, Y Hu, S Zhang, J Fu, XM Wang…

Index: Luo, Yin; Zhang, Li-Rong; Hu, Yang; Zhang, Shuai; Wang, Xiao-Ming; Zhu, Hai-Liang; Fu, Jie ChemMedChem, 2012 , vol. 7, # 9 p. 1587 - 1593,7

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Citation Number: 6

Abstract

Abstract Forty-three oxime derivatives were synthesized by allowing O- benzylhydroxylamines to react with primary benzaldehydes or salicylaldehydes; these products were gauged as potential inhibitors of β-ketoacyl-(acyl-carrier-protein) synthase III (FabH). Among the 43 compounds, 38 are reported herein for the first time. These compounds were assayed for antimicrobial activities against Escherichia coli, ...