Three approaches to the synthesis of L-leucine selectively labelled with carbon-13 or deuterium in either diastereotopic methyl group

…, NM Kelly, H Schmalz, A Sutherland…

Index: Fletcher, Matthew D.; Harding, John R.; Hughes, Rachael A.; Kelly, Nicholas M.; Schmalz, Holger; Sutherland, Andrew; Willis, Christine L. Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 1 p. 43 - 52

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Citation Number: 13

Abstract

Three approaches to the synthesis of l-leucine selectively labelled with carbon-13 or deuterium in either diastereotopic methyl group as well as at C-3 and C-4 are described. In all three methods the stereogenic centre at C-2 was created with total stereocontrol via a one-pot, two-enzyme catalysed procedure