Abstract A number of new [(pyrazol-4-yl) methylene] hydrazono-2, 3-dihydrothiazole derivatives, their sugar hydrazones and N-glycosides were synthesized. Furthermore, N- substituted oxygenated alkyl and hydroxyl derivatives and 1, 3, 4,-oxadiazoline acyclic nucleoside analogs were prepared. The newly synthesized compounds were tested for their antimicrobial activities and showed moderate to high inhibition activities. J. Heterocyclic ...