Figure 1. Inhibition of TxBz production in whole blood from dogs following a single oral dose of 21. 6 and the ester 7, respectively. Compound 6 was prepared to provide a comparison with a nonacidic N-substituent. Nitrile precursors (8-17) to N-propanoic acid derivatives were prepared by treatment of a 3-(1H-imidazol-l-ylmethyl)-1H-indole with acrylonitrile in dioxane in the presence of benzyltrimethylammonium hydroxide. Treatment of 3 with ethyl ...