Selective thromboxane synthetase inhibitors. 2. 3-(1H-Imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogs.

…, RP Dickinson, MJ Parry, MJ Randall

Index: Cross, Peter E.; Dickinson, Roger P.; Parry, M. John; Randall, Michael J. Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 342 - 346

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Citation Number: 41

Abstract

Figure 1. Inhibition of TxBz production in whole blood from dogs following a single oral dose of 21. 6 and the ester 7, respectively. Compound 6 was prepared to provide a comparison with a nonacidic N-substituent. Nitrile precursors (8-17) to N-propanoic acid derivatives were prepared by treatment of a 3-(1H-imidazol-l-ylmethyl)-1H-indole with acrylonitrile in dioxane in the presence of benzyltrimethylammonium hydroxide. Treatment of 3 with ethyl ...