Amination of 4??nitro??and 4??cyanopyridazines by liquid ammonia/potassium permanganate

…, H Tondijs, HC Van Der Plas

Index: Marcelis, Antonius T. M.; Tondijs, Hanna; Plas, Henk C. van der Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 831 - 833

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Citation Number: 8

Abstract

Abstract 4-Nitro-3-R 1-6-R 2-pyridazines (1)(a, R 1= R 2= 2-pyridyl; b, R 1= H, R 2= phenyl; e, R 1= H, R 2= p-methoxyphenyl; d, R 1= R 2= H) are aminated by liquid ammonia/potassium permanganate to the corresponding 5-amino-4-nitropyridazines 3a-d. The 4-cyano-3-R 1-6-R 2-pyridazines 4a, b are only aminated in the presence of potassium amide in liquid ammonia/potassium permanganate to give the 5-amino-4- ...