Synthesis and bioactivity of N-tert-butyl-N′-acyl-5-methyl-1, 2, 3-thiadiazole-4-carbohydrazides

…, XT Ji, XW Hua, T Kalinina, YM Yury, AB Vasiliy

Index: Mao, Wu Tao; Zhao, Hui; Fan, Zhi Jin; Ji, Xiao Tian; Hua, Xue Wen; Kalinina, Tatiana; Yury, Yu. Morzherin; Vasiliy, A. Bakulev Chinese Chemical Letters, 2012 , vol. 23, # 11 p. 1233 - 1236,4

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Citation Number: 6

Abstract

A series of novel N-tert-butyl-N′-acyl-5-methyl-1, 2, 3-thiadiazole-4-carbohydrazides were designed and synthesized. Their structures were characterized by melting points, 1H NMR, IR, ESI-MS, and elemental analysis. The bioassay tests indicated that compound 7o exhibited excellent direct anti-TMV activity and induction activity in vivo at 50μg/mL, which was better than that of Ninamycin and tiadinial. Our studies indicated that 1, 2, 3- ...