Synthesis and reactions of 1, 2, 4-triazine azides with triphenylphosphine, trialkyl phosphites and dialkyl phosphonates

YO El-Khoshnieh

Index: El-Khoshnieh, Yehia O. Phosphorus, Sulfur and Silicon and Related Elements, 1998 , vol. 139, p. 163 - 172

Full Text: HTML

Citation Number: 8

Abstract

Abstract 3-Azido-5, 6-diphenyl-1, 2, 4-triazine (1) and 3-azidophenanthro [9, 10-e]-1, 2, 4- triazine (2) are synthesized in high yield (∼ 75%). 1 and 2 react with triphenylphosphine to afford phosphazenes 5 and 6 with a covalent structure. Reactions of 1 and 2 with trialkylphosphites 3b, c produce phosphazenes 7a, b and 8a, b which have the phosphonium dipolar ion structure, 1 reacts with diethyl phosphonate (4a) to give the ...

~72%

~88%

~89%

Discovery of 1, 2, 4-triazine derivatives as adenosine A2A a...

[Congreve, Miles; Andrews, Stephen P.; Dore, Andrew S.; Hollenstein, Kaspar; Hurrell, Edward; Langmead, Christopher J.; Mason, Jonathan S.; Ng, Irene W.; Tehan, Benjamin; Zhukov, Andrei; Weir, Malcolm; Marshall, Fiona H. Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 1898 - 1903]