A concise route to iboga-analogues has been developed. Important steps include a Pd- catalyzed Sonogashira coupling of Boc-2-idodaniline with terminal alkynes and the formation of 2-substituted indoles in the presence of tetrabutylammonium fluoride to give the key intermediate, dehydroisoquinuclidine-containing indole. The final step cyclization between indole-3-position and dehydroisoquinuclidine ring was achieved using Pd (II)– ...
