Affinity??Based Labeling of Cytohesins with a Bifunctional SecinH3 Photoaffinity Probe

X Bi, A Schmitz, AM Hayallah, JN Song…

Index: Bi, Xihe; Schmitz, Anton; Hayallah, Alaa M.; Song, Jin-Na; Famulok, Michael Angewandte Chemie - International Edition, 2008 , vol. 47, # 49 p. 9565 - 9568

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Citation Number: 22

Abstract

We recently identified the 1, 2, 4-triazole derivative SecinH3 (see Scheme 1) as the first small-molecule inhibitor of a class of cytoplasmic regulatory proteins called cytohesins by using an aptamer-displacement assay.[1, 2] Cytohesins are small guanine nucleotide exchange factors (GEFs) that stimulate ADP (adenosine diphosphate) ribosylation factors (Arfs), ubiquitously expressed Ras-like GTPases which control various cellular regulatory ...